Publication

2025

Journal

• "Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition"
  Antonino Glaviano, Hannah Si-Hui Lau, Lukas M Carter, E Hui Clarissa Lee, Hiu Yan Lam, Elena Okina, Donavan Jia Jie Tan, Wency Tan, Hui Li Ang, Daniela Carbone, Michelle Yi-Hui Yee, Muthu K Shanmugam, Xiao Zi Huang, Gautam Sethi, Tuan Zea Tan, Lina HK Lim, Ruby Yun-Ju Huang, Hendrik Ungefroren, Elisa Giovannetti, Dean G Tang, Tullia C Bruno, Peng Luo, Mads Hald Andersen, Bin-Zhi Qian, Jun Ishihara, Derek C Radisky, Salem Elias, Saurabh Yadav, Minah Kim, Caroline Robert, Patrizia Diana, Kurt A Schalper, Tao Shi, Taha Merghoub, Simone Krebs, Anjali P Kusumbe, Matthew S Davids, Jennifer R Brown, Alan Prem Kumar
  Hematol Oncol (2025).

  • DOI: 10.1186/s13045-024-01634-6

2024

Journal

• "Engineered GM-CSF polarizes protumorigenic tumor-associated macrophages to an antitumorigenic phenotype and potently synergizes with IL-12 immunotherapy"
  Seounghun Kang, Aslan Mansurov, Trevin Kurtanich, Hye Rin Chun, Anna J Slezak, Lisa R Volpatti, Kevin Chang, Thomas Wang, Aaron T Alpar, Kirsten C Refvik, O Isabella Hansen, Gustavo J Borjas, Brendan TK Berg, Ha-Na Shim, Kevin T Hultgren, Suzana Gomes, Yue Wang, Ani Solanki, Jun Ishihara, Melody A Swartz, Jeffrey A Hubbell
  Journal for immunotherapy of cancer Dec 22;12(12):e009541 (2024).

  • DOI: 10.1136/jitc-2024-009541

2023

Journal

• "Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy"
  Bhatia, V.; Kamat, N. V.; Pariva, T. E.; Wu, L.-T.; Tsao, A.; Sasaki, K.; Sun, H.; Javier, G.; Nutt, S.; Coleman, I.; Hitchcock, L.; Zhang, A.; Rudoy, D.; Gulati, R.; Patel, R. A.; Roudier, M. P.; True, L. D.; Srivastava, S.; Morrissey, C. M.; Haffner, M. C.; Nelson, P. S.; Priceman, S. J.; Ishihara, J.; Lee, J. K
  Nature communications 14 (1), 2041 (2023).

  • DOI: https://doi.org/10.21417/VB2023NC
• "Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicity"
  Seounghun Kang, Aslan Mansurov, Trevin Kurtanich, Hye Rin Chun, Anna J Slezak, Lisa R Volpatti, Kevin Chang, Thomas Wang, Aaron T Alpar, Kirsten C Refvik, O Isabella Hansen, Gustavo J Borjas, Ha-Na Shim, Kevin T Hultgren, Suzana Gomes, Ani Solanki, Jun Ishihara, Melody A Swartz, Jeffrey A Hubbell
  Science Advances (2023).

  • DOI: 10.1126/sciadv.adh9879
• "An engineered immunocytokine with collagen affinity improves the tumor bioavailability, tolerability, and therapeutic efficacy of IL-2"
  Aliyah B Silver , Stephany Y Tzeng , Mallory Lager , Jeremy Wang, Jun Ishihara, Jordan J Green, Jamie B Spangler
  Cell Rep Med Nov 21;4(11):101289 (2023).

  • DOI: 10.1016/j.xcrm.2023.101289
• "Capillary-Scale Hydrogel Microchannel Networks by Wire Templating "
  Kawara S, Cunningham B, Bezer J, Neelima KC,1 Jingwen Zhu,1 Meng-Xing Tang, Ishihara J, Choi JJ, Au S
  Small (2023).
• "The Clinical Terrain of Immunotherapies in Heterogeneous Pancreatic Cancer: Unravelling Challenges and Opportunities"
  Herpels M, Ishihara J, Sadanandam A
  Journal of pathology (2023).
• "Topically-Applied Collagen-Binding Serum Albumin-Fused Interleukin-4 Potentiates Wound Healing in a Type 2 Diabetic Mouse Model "
  Lauterbach AL, Wallace RP, Alpar AT, Refvik KC, Ako Ishihara, Beckman TN, Slezak AJ, Mansurov A, Gomes S, Ishihara J#, Hubbell JA #
  NPJ regenerative medicine (2023).
• "Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting"
  Lee EHJ., Cullen C, Murad JP, Gumber D, Park AK, Yang J, Stern LA, Adkins LN, Dhapola G, Gittins B, Chang W, Ishihara J, Lee JL, Forman SJ, Wang LD, Priceman SJ.
  Nature communications (2023).

2022

Journal

• "Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker"
  Mansurov A, Hosseinchi P, Chang K, Lauterbach AL, Gray LT, Alpar AT, Budina E, Slezak AJ, Kang S, Cao S, Solanki A, Gomes S, Williford JM, Swartz MA, Mendoza JL, Ishihara J, Hubbell JA.
  Nature Biomedical Engineering (2022).

  • DOI: 10.1038/s41551-022-00888-0
• "Emerging approaches for preventing cytokine release syndrome in CAR-T cell therapy"
  Srinivas Balagopal, Koichi Sasaki, Pooja Kaur, Maria Nikolaidi, Jun Ishihara
  (2022).

  • DOI: 10.1039/d2tb00592a

2021

Journal

• "Prolonged residence of an albumin–IL-4 fusion protein in secondary lymphoid organs ameliorates experimental autoimmune encephalomyelitis"
  Ishihara A, Ishihara J#, Watkins EA, Tremain AC, Nguyen M, Solanki A, Katsumata K, Mansurov A, Budina E, Alpar AT, Hosseinchi P, Maillat L, Reda JW, Kageyama T, Swartz MA, Yuba E, Hubbell JA#
  Nature Biomedical Engineering 5, pages387–398 (2021).

  • DOI: 10.1038/s41551-020-00627-3
• "Suppression of Rheumatoid Arthritis by Enhanced Lymph Node Trafficking of Engineered Interleukin-10 in Murine Models"
  Eiji Yuba, Erica Budina, Kiyomitsu Katsumata, Ako Ishihara, Aslan Mansurov, Aaron T Alpar, Elyse A Watkins, Peyman Hosseinchi, Joseph W Reda, Abigail L Lauterbach, Mindy Nguyen, Ani Solanki, Takahiro Kageyama, Melody A Swartz, Jun Ishihara#, Jeffrey A Hubbell#
  Arthritis & rheumatology 73, 5, 769-778 (2021).

  • DOI: 10.1002/art.41585
• "Lymphangiogenesis-inducing vaccines elicit potent and long-lasting T cell immunity against melanomas"
  Sasso MS, Mitrousis N, Wang Y, Briquez PS, Hauert S, Ishihara J, Hubbell JA, Swartz MA
  Science Advances 7, 13, eabe4362 (2021).

  • DOI: 10.1126/sciadv.abe4362
• "Immunoengineering approaches for cytokine therapy"
  Aslan Mansurov, Abigail Lauterbach, Erica Budina, Aaron T Alpar, Jeffrey A Hubbell, Jun Ishihara
  Am J Physiol Cell Physiol 1, 321(2), C369-C383 (2021).

  • URL
  • DOI: 10.1152/ajpcell.00515.2020

2020

Journal

• "Collagen-binding IL-12 enhances tumour inflammation and drives the complete remission of established immunologically cold mouse tumours"
  Mansurov A*, Ishihara J#*, Hosseinchi P, Potin L, Marchell TM, Ishihara A, Williford J-M, Alpar AT, Raczy MM, Gray LT, Swartz MA, Hubbell JA
  Nature Biomedical Engineering 4, 531-543 (2020).

2019

Journal

• "Conferring extracellular matrix affinity enhances local therapeutic efficacy of anti-TNF-α antibody in a murine model of rheumatoid arthritis"
  Katsumata K, Ishihara J, Fukunaga K, Ishihara A, Yuba E, Budina E, Hubbell JA
  Arthritis Research and Therapy 21, 1-10 (2019).
• "Recruitment of CD103+ dendritic cells via tumor-targeted chemokine delivery enhances efficacy of checkpoint inhibitor immunotherapy"
  Williford J-M*, Ishihara J*, Ishihara A, Mansurov A, Hosseinchi P, Marchell TM, Potin L, Swartz MA, Hubbell JA
  Science Advances 5, 1-15 (2019).

  • DOI: 10.1126/sciadv.aay1357
• "Targeting inflammatory sites through collagen affinity enhances the therapeutic efficacy of anti-inflammatory antibodies"
  Katsumata K, Ishihara J, Mansurov A, Ishihara A, Raczy MM, Yuba E, Hubbell JA
  Science Advances 5, 1-9 (2019).

  • DOI: 10.1126/sciadv.aay1971
• "Engineered collagen-binding serum albumin as a drug conjugate carrier for cancer therapy"
  Sasaki K*, Ishihara J*, Ishihara A, Miura R, Mansurov A, Fukunaga K, Hubbell JA
  Science Advances 5, 1-12 (2019).

  • DOI: 10.1126/sciadv.aaw6081
• "The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing"
  Ishihara J, Ishihara A, Starke RD, Peghaire CR, Smith KE, McKinnon TAJ, Tabata Y, Sasaki K, White MJV, Fukunaga K, Laffan MA, Lutolf MP, Randi AM, Hubbell JA
  Blood 133, 2559-2569 (2019).

  • DOI: 10.1182/blood.2019000510
• "Targeted antibody and cytokine cancer immunotherapies through collagen affinity"
  Ishihara J*, Ishihara A*, Sasaki K, Lee SS-Y, Williford J-M, Yasui M, Abe H, Potin L, Hosseinchi P, Fukunaga K, Raczy MM, Gray LT, Mansurov A, Katsumata K, Fukayama M, Kron SJ, Swartz MA, Hubbell JA
  Science Translational Medicine 11, 1-13 (2019).

  • DOI: 10.1126/scitranslmed.aau3259

2018

Journal

• "Improving Efficacy and Safety of Agonistic Anti-CD40 Antibody Through Extracellular Matrix Affinity"
  Ishihara J*, Ishihara A*, Potin L, Hosseinchi P, Fukunaga K, Damo M, Gajewski TF, Swartz MA, Hubbell JA
  Molecular Cancer Therapeutics 17, 2399-2411 (2018).

  • DOI: 10.1158/1535-7163.MCT-18-0091
• "Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing"
  Ishihara J, Ishihara A, Fukunaga K, Sasaki K, White MJV, Briquez PS, Hubbell JA
  Nature Communications 9, 1-14 (2018).

2017

Journal

• "Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events"
  Ishihara J, Fukunaga K, Ishihara A, Larsson HM, Potin L, Hosseinchi P, Galliverti G, Swartz MA, Hubbell JA
  Science Translational Medicine 9, 1-16 (2017).

2015

Journal

• "Stripe‐Patterned Thermo‐responsive Cell Culture Dish for Cell Separation without Cell Labeling"
  Kumashiro Y, Ishihara J, Umemoto T, Itoga K, Kobayashi J, Shimizu T, Yamato M, Okano T
  Small 11, 681-687 (2015).

  • DOI: 10.1002/smll.201400787

2014

Journal

• "A role for c-Kit in the maintenance of undifferentiated human mesenchymal stromal cells"
  Suphanantachat S, Iwata T, Ishihara J, Yamato M, Okano T, Izumi Y
  Biomaterials 35, 3618-3626 (2014).

  • DOI: 10.1016/j.biomaterials.2014.01.031
• "Nov/CCN3 regulates long-term repopulating activity of murine hematopoietic stem cells via integrin αvβ3"
  Ishihara J, Umemoto T, Yamato M, Shiratsuchi Y, Takaki S, Petrich BG, Nakauchi H, Eto K, Kitamura T, Okano T
  International Journal of Hematology 99, 393-406 (2014).

2012

Journal

• "Requirement of Integrin β3 for Iron Transportation during Enamel Formation"
  Yoshida T, Kumashiro Y, Iwata T, Ishihara J, Umemoto T, Shiratsuchi Y, Kawashima N, Sugiyama T, Yamato M, Okano T
  Journal of Dental Research 91, 1154-1159 (2012).

  • DOI: 10.1177/0022034512462722
• "Integrin-αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells"
  Umemoto T, Yamato M, Ishihara J, Shiratsuchi Y, Utsumi M, Morita Y, Tsukui H, Terasawa M, Shibata T, Nishida K, Kobayashi Y, Petrich BG, Nakauchi H, Eto K, Okano T
  Blood 119, 1, 83-94 (2012).

  • DOI: 10.1182/blood-2011-02-335430