Research
Making cancer therapy safe and effective
Publications:
Sasaki, K., Bhatia, V., Asano, Y. et al. Collagen-binding IL-12-armoured STEAP1 CAR-T cells reduce toxicity and treat prostate cancer in mouse models. Nat. Biomed. Eng (2025). https://doi.org/10.1038/s41551-025-01508-3
Mansurov A, Ishihara J, Hosseinchi P, Potin L, Marchell TM, Ishihara A, Williford J-M, Alpar AT, Raczy MM, Gray LT, Swartz MA, Hubbell JA, 2020, Collagen-binding IL-12 enhances tumour inflammation and drives the complete remission of established immunologically cold mouse tumours, Nature Biomedical Engineering, Vol: 4, Pages: 531-543
Ishihara J, Ishihara A, Sasaki K, Lee SS-Y, Williford J-M, Yasui M, Abe H, Potin L, Hosseinchi P, Fukunaga K, Raczy MM, Gray LT, Mansurov A, Katsumata K, Fukayama M, Kron SJ, Swartz MA, Hubbell JA, 2019, Targeted antibody and cytokine cancer immunotherapies through collagen affinity, Science Translational Medicine, Vol: 11, Pages: eaau3259-eaau3259, ISSN: 1946-6234
Ishihara J, Ishihara A, Potin L, Hosseinchi P, Fukunaga K, Damo M, Gajewski TF, Swartz MA, Hubbell JA, 2018, Improving Efficacy and Safety of Agonistic Anti-CD40 Antibody Through Extracellular Matrix Affinity, Molecular Cancer Therapeutics, Pages: molcanther.0091.2018-molcanther.0091.2018, ISSN: 1535-7163
Ishihara J, Fukunaga K, Ishihara A, Larsson HM, Potin L, Hosseinchi P, Galliverti G, Swartz MA, Hubbell JA, 2017, Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events, Science Translational Medicine, Vol: 9, Pages: eaan0401-eaan0401, ISSN: 1946-6234