Jun Ishihara(Assistant Professor)
Dr. Jun Ishihara is a Lecturer (equivalent to Assistant Professor in the USA) in the Department of Bioengineering at Imperial College London. The Ishihara laboratory works in the field of protein engineering, with research foci in cancer immunotherapy, autoimmunity, and regenerative medicine.
Dr. Ishihara received his PhD in stem cell biology from the University of Tokyo. He then conducted postdoctoral training in the laboratory of Jeffrey Hubbell first at the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland from 2014 to 2016 and then at the University of Chicago from 2016 to 2020 when the laboratory relocated to the Pritzker School of Molecular Engineering.
Dr. Ishihara has developed novel technologies in the field of immuno-engineering in order to improve current therapies and discover new drugs. He has developed novel approaches to cancer immunotherapy that achieve localised immune activation by targeting the tumour microenvironment. These methods make cancer immunotherapy safe and effective. Dr. Ishihara has also engineered treatments for autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. In the field of regenerative medicine, he has developed novel approaches to efficiently deliver growth factors to the wound site to promote wound healing.
Dr. Ishihara has co-authored 19 scientific papers and 16 patents, with publications in Nature Biomedical Engineering, Science Translational Medicine, Science Advances, Blood and Nature Communications. He is also a co-founder of Arrow Immune Inc., focusing on clinical translation of cancer immunotherapy techniques, HeioThera Inc., focusing on clinical translation of anti-inflammatory the therapeutics, and ScienceLounge LLC., which runs a science bar in Tokyo for scientific outreach activities.
Ishihara A, Ishihara J#, Watkins EA, Tremain AC, Nguyen M, Solanki A, Katsumata K, Mansurov A, Budina E, Alpar AT, Hosseinchi P, Maillat L, Reda JW, Kageyama T, Swartz MA, Yuba E, Hubbell JA#
Nature Biomedical Engineering 5, pages387–398 (2021). DOI:10.1038/s41551-020-00627-3
Mansurov A*, Ishihara J#*, Hosseinchi P, Potin L, Marchell TM, Ishihara A, Williford J-M, Alpar AT, Raczy MM, Gray LT, Swartz MA, Hubbell JA
Nature Biomedical Engineering 4, 531-543 (2020).
Williford J-M*, Ishihara J*, Ishihara A, Mansurov A, Hosseinchi P, Marchell TM, Potin L, Swartz MA, Hubbell JA
Science Advances 5, 1-15 (2019). DOI:10.1126/sciadv.aay1357
Ishihara J, Ishihara A, Starke RD, Peghaire CR, Smith KE, McKinnon TAJ, Tabata Y, Sasaki K, White MJV, Fukunaga K, Laffan MA, Lutolf MP, Randi AM, Hubbell JA
Blood 133, 2559-2569 (2019). DOI:10.1182/blood.2019000510
Ishihara J*, Ishihara A*, Sasaki K, Lee SS-Y, Williford J-M, Yasui M, Abe H, Potin L, Hosseinchi P, Fukunaga K, Raczy MM, Gray LT, Mansurov A, Katsumata K, Fukayama M, Kron SJ, Swartz MA, Hubbell JA
Science Translational Medicine 11, 1-13 (2019). DOI:10.1126/scitranslmed.aau3259
Umemoto T, Yamato M, Ishihara J, Shiratsuchi Y, Utsumi M, Morita Y, Tsukui H, Terasawa M, Shibata T, Nishida K, Kobayashi Y, Petrich BG, Nakauchi H, Eto K, Okano T
Blood 119, 1, 83-94 (2012). DOI:10.1182/blood-2011-02-335430